In the kidneys, moderate basophilia of the tubules with slight degeneration and cellular sloughing was observed.
Prosztatagyulladás korai stádiumainak kezelése Prostate adenoma prostate gland and the degree of sexual activity in men are not interrelated. Currently, it is recognized that prostate adenoma is observed in blacks more often, as has been proven when studying the epidemiological situation in various regions of the world.
These kidney findings may have contributed to the moribund condition of the animal. Lymphoid atrophy in the thymus, lymphoid depletion in the spleen and possibly the ductal degranulation of the submandibular glands, reflect the moribund condition of the animal.
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The marked lymphocytolyis in the thymus and possibly the ductal normal size prostate gland cm of the submandibular glands as well, reflect the moribund condition of the animal. No indications for the cause of death was found on the sections examined.
The marked lymphocytolyis in the thymus and possibly the ductal degranulation of the submandibular glands, reflect the moribund condition of the animal.
No indications for the cause of death was found on the section examined. There were no further indications for a possible procedural error.
Findings in both the kidney and larynx may have contributed to the moribund condition of the animal. The marked lymphoid depletion in the thymus and possibly the ductal degranulation of the submandibular glands, reflect the moribund condition of the animal. The study was based on the following guidelines.
Study outline The test substance, formulated in water Elixwas administered daily for at least 90 days by oral gavage to SPF-bred Wistar rats. One control group and three treated groups were tested, each consisting of 10 males and 10 females.
Evaluated parameters Chemical analyses of formulations were conducted three times during the study Weeks 1, 6 and 13 to assess accuracy, homogeneity and stability over 6 hours.
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The following parameters were evaluated: clinical signs daily; functional observation tests in Week ; body weight and food consumption weekly; ophthalmoscopy at pretest and in Week 13; clinical pathology and macroscopy at termination; organ weights and histopathology on a selection of tissues. Results Formulation analyses confirmed that formulations of test substance in water Elix were prepared accurately and homogenously, and were stable when stored at room temperature under normal laboratory light conditions for at least 6 hours and in a refrigerator for at least 8 days.
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Three new females were dosed from Day 8 up to and including Day One male was dosed from Day 8 up to scheduled day of necropsy. The slightly shorter exposure period of 84 days in this single animal was considered not to influence the results of the study.
Other clinical signs noted in these animals at lower incidence comprised of hunched posture, laboured respiration, piloerection, chromodacryorrhoea, dehydrated appearance. Based on the low incidence and the expected reversibility no toxicological significance was ascribed to these clinical signs. All other females showed a normal regular estrous cycle of 4 days.
Therefore these changes were considered not adverse in this study. Very slight changes in clinical biochemistry parameters were considered to be related to treatment based on the dose related response.
Since all values were within the range expected for rats of this age and strain in this kind of study and since no corroborative adverse findings were noted at histopathological examination, these changes are considered to be not adverse.
Since in some studies it may be observed as background finding and the severity is only minor, this finding is not considered to be adverse. No toxicologically significant changes were normal size prostate gland cm in the remaining parameters observed in this study: functional observations, ophthalmoscopy, heamatological parameters, macroscopic examination and organ weights. Endpoint conclusion.
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